Post-doctorat endocrinologie moléculaire (24 mois)

Genetics, Reproduction & Development (GReD), CNRS UMR6293-Inserm U1103-Clermont Université Dir. Dr. Chantal VAURY

Team 10 Dir. Dr. Antoine MARTINEZ

GReD– BP80026, 24 avenue des Landais 63171 Aubière – France Tel : +33 (0)4 73 40 74 09 ; Fax : + 33 (0)4 73 40 70 42 ; e-mail : antoine.martinez@univ-bpclermont.fr

POST-DOCTORAL POSITION IN DEVELOPMENT, MICRO-ENVIRONMENT & GENETIC ALTERATIONS IN ADRENAL LESIONS WITHIN CARNEY COMPLEX, CLERMONT-FD, FRANCE

A twenty four-month postdoctoral position is available in team 10 – Adrenocortical Tumorigenesis & Adipose Tissue Homeostasis directed by Dr. Antoine Martinez at GReD laboratories CNRS UMR6293, INSERM U1103 in Clermont-Ferrand.

The position is funded by a grant of the Agence Nationale de la Recherche. It will start as soon as possible, it has no nationality restriction and the working language is French and/or English.

Our recent studies have been focusing on the pathophysiological mechanisms leading to benign and malignant tumors of the adrenal cortex. Our lab has contributed to the development of the first mouse models for adrenal endocrine diseases and tumors and now coordinates a collaborative project bringing together the best clinical experts of Carney complex (CNC) disease and basic researchers specialised in mouse development and endocrinology. CNC is a genetic disease responsible for myxomas and various endocrine tumors including hypersecreting adrenal lesions. PRKAR1A, the main gene mutated in CNC, encodes the R1αregulatory subunit of PKA. By collecting a unique worldwide CNC cohort and developing mouse models, we have shown that R1αis a tumor suppressor whose loss induces expansion and reprogramming of pluripotent foetal cells within adult tissues. These findings qualified CNC as a progenitor cell disease. Our project is now to 1) demonstrate the progenitor origin of the lesions by lineage tracing studies in mice 2) assess contribution of PKA catalytic subunits and microenvironment in pathogenesis 3) identify new pathogenic mechanisms by expressing R1α mutants found in severe forms in TG mice. This project should provide novel insights into stem/progenitor biology of the adrenal and in depth understanding of diseases associated with unbalanced PKA signaling

Applicants should have just received their PhD degree. Applicants with previous post-doctoral experience are not eligible. We are looking for highly motivated scientists with background in genetics, molecular and cellular biology, as well as in phenotypic investigation of mouse models. Skills in bioinformatics and in in silico analyses will be appreciated. Propensity to work with mice is highly recommended.

The team is part of GReD Laboratories, a research unit created to foster expertise in basic genetics, development and endocrinology in Clermont area. Located on Cézeaux campus in Aubière and at Medical School in Clermont-Fd, it houses research teams with a broad range of expertise in genetics and integrative physiology research using plant or animal models as well as state-of-the-art technology platforms (transgenic mouse facility, confocal imaging, animal histopathology, fly facility).

Address applications (preferably by email), including a cover letter outlining your motivation and a short summary of your past research, CV + List of publications, and names/e-mail addresses of at least two referees to:

Antoine Martinez, PhD
CNRS UMR6293, Clermont Université, INSERM U1103 GReD – Génétique, Reproduction & Développement
BP80026, 24 avenue des Landais – 63171 Aubière cedex
Tél: 33 (0)4 73 40 74 09 – Fax: 33 (0)4 73 40 70 42 

  Mail: antoine.martinez@univ-bpclermont.fr

Web site: https://www.gred-clermont.fr/